• Indication
  • Mode of Action
  • Pharmacokinetics
  • Dosage
  • Packing

Fungal infections of the skin caused by Trichophyton (eg. T. Rubrum, T.Mentagrophytes, T. Verrucosum, T. Violaceum), Microsporum canis and Epidermophyton floccosum. Yeast infections of the skin, principally those caused by the genus Candida (eg. C. albicans). Pityriasis (tinea) versicolor due to Pityrosporum orbiculare (also known as Malassezia furfur).

Terbinafine is an allylamine which has a broad spectrum of antifungal activity. At low concentrations Terbinafine is fungicidal against dermatophytes, molds and certain dimorphic fungi. The activity versus yeasts is fungicidal or fungistatic depending of the species. Terbinafine interferes specifically with fungal sterol biosynthesis at an early step. This leads to a deficiency in ergosterol and to an intracellular accumulation of squalene, resulting in fungal cell death. Terbinafine acts by inhibition of squalene epoxidase in the fungal cell membrane. The enzyme squalene epoidase is not linked to the cytochrome P450 system.

Less than 5% of the dose is absorbed after topical application to humans; systemic exposure is therefore very slight

Dosage & Administration: Terbest Cream can be applied once or twice daily.The likely duration of each treatment is as follows: Tinea corporis, cruris--1 to 2 weeks, Tinea pedis--1 weeks Cutaneous candidiasis--2 weeks , Pityriasis versicolor--2 weeks Relief of clinical symptoms usually occurs within a few days. Irregular use or premature discontinuation of treatment carries the risk of recurrence. If there are no signs of improvement after two weeks, the diagnosis should be verified. Cleanse and dry the affected areas thoroughly before application of TERBINAFINE. Apply the cream to the affected skin and surrounding area in a thin layer and rub in lightly. In the case of intertriginous infections (submammary, interdigital, intergluteal, inguinal) the application may be covered with a gauze strip, especially at night.

TERBEST Cream is available in 10 g of pack filled in laminated tube & packed in Carton.