• Indication
  • Mode of Action
  • Pharmacokinetics
  • Dosage
  • Packing

Silver Sulfadiazine Cream 1% w/w is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second and third-degree burns. Sulfadiazine is a short-acting sulphonamide with bacteriostatic activity against a broad spectrum of organisms. Gram-positive: Particularly group A Streptococci and some strains of Streptococcus pneumoniae, Bacillus ant hracis, Nocardia (especially N.asteroides) and, to a lesser extent, Staphylococci and Clostridium perfringens. Gram-negative: Haemophilus influenzae and H.ducreyi are often sensitive, sensitivity varies among the enterobacteriae-Escherichia coli, Klebsiella, proteus, Salmonella and Serratia and Vibrio cholerae are sometimes sensitive. Other organisms reported to be sensitive include, Actinomyces spP., Brucella, Calymmatobacterium granulomatis, Legionella, Yersinia pestis, Chlamydia, Pseudomonas pseudomallei.

Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below. Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.

No data available since it is a topical application.

The burn wounds are cleansed and debrided, and Silver Sulfadiazine Cream 1% w/w is applied under sterile conditions. The burn areas should be covered with Silver Sulfadiazine Cream 1% w/w at all times. The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. Whenever necessary, the cream should be reapplied to any areas from which it has been removed by patient activity. Administration may be accomplished in minimal time because dressings are not required. However, if individual patient requirements make dressings necessary, they may be used. Reapply immediately after hydrotherapy. Treatment with Silver Sulfadiazine Cream 1% w/w should be continued until satisfactory healing has occurred, or until the burn site is ready for grafting. The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.

SULFATOP Cream is available in 15 g of pack filled in laminated tube & packed in Carton.