• Indication
  • Mode of Action
  • Pharmacokinetics
  • Dosage
  • Packing

Butenafine Hydrochloride Cream is indicated for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur (formerly Pityrosporum orbiculare).

It is hypothesized that butenafine HCl inhibits the growth of fungi by inhibiting the epoxidation of squalene, thus blocking the biosynthesis of ergosterol, an essential component of the fungal cell membrane. Lack of or diminished quantities of ergosterol in the fungal cell membrane injures the cell causing inhibition of growth. Results of nonstandardized in vitro susceptibility tests suggest that butenafine HCl has activity against Malassezia furfur (formerly Pityrosporum orbiculare).

Less than 5% of the dose is absorbed after topical application to humans; systemic exposure is therefore very slight.

Butenafine Hydrochloride Cream can be applied once daily for two weeks. It should be applied to cover affected areas and immediately surrounding skin of patients with tinea versicolor. If a patient shows no clinical improvement after the treatment period, the diagnosis and therapy should be reviewed.

BUTEF Cream is available in 30 g of pack filled in laminated tube & packed in Carton.