• Indication
  • Mode of Action
  • Pharmacokinetics
  • Dosage
  • Packing

For the treatment of: • All dermatomycoses due to moulds and other fungi (e.g. Trichophyton species) • All dermatomycoses due to yeasts (Candida species). These include ringworm (tinea) infections (e.g. athlete's foot), paronychia, pityriasis versicolor, erythrasma and intertrigo. • Skin diseases showing secondary infection with these fungi. • Candidal nappy rash, vulvitis and balanitis.

Clotrimazole acts against fungi by inhibiting ergosterol synthesis. Inhibition of ergosterol synthesis leads to structural and functional impairment of the cytoplasmic membrane. Clotrimazole has a broad antimycotic spectrum of action in vitro and in vivo, which includes dermatophytes, yeasts, moulds, etc. Under appropriate test conditions, the MIC values for these types of fungi are in the region of less than 0.062-8.0 µg/ml substrate. The mode of action of Clotrimazole is primarily fungistatic or fungicidal depending on the concentration of Clotrimazole at the site of infection. In vitro activity is limited to proliferating fungal elements; fungal spores are only slightly sensitive. In addition to its antimycotic action, Clotrimazole also acts on gram-positive microorganisms (Streptococci / Staphylococci / Gardnerella vaginalis), and gram-negative microorganisms (Bacteroides). In vitro Clotrimazole inhibits the multiplication of Corynebacteria and gram-positive cocci - with the exception of Enterococci - in concentrations of 0.5-10 µg/ml substrate.

Pharmacokinetic investigations after dermal application have shown that Clotrimazole is minimally absorbed from the intact or inflamed skin into the human blood circulation. The resulting peak serum concentrations of Clotrimazole were below the detection limit of 0.001 mcg/ml, suggesting that Clotrimazole applied topically is unlikely to lead to measurable systemic effects or side effects.

There is no separate dosage schedule for the young or elderly. The cream should be applied thinly and evenly to the affected area 2 – 3 times daily and rubbed in gently. A strip of cream (½ cm long) is enough to treat an area of about the size of the hand. If the feet are infected, they should be thoroughly washed and dried, especially between the toes, before applying the cream. Treatment should be continued for at least one month for dermatophyte infections, or for at least two weeks for candidal infections.

TOPICLO Cream is available in 30 g of pack filled in laminated tube & packed in Carton.