Mozart-AM

Losartan block the vasoconstrictor and aldosterone secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues. Amlodipine is a calcium antagonist that inhibits influx of calcium ions into vascular smooth muscle and cardiac muscle.

Losartan is well absorbed; systemic bioavailability is about 33%; about 14% of an oral dose is converted to active metabolites. Amlodipine's peak plasma level is 6-12hr; bioavailability 64-90%; 93% bound to plasma proteins.

Adult: initial one tablet once daily; may increase to 2 tablets daily if the BP control is inadequate after 1-2weeks.

Available as a blister strip of 10 tablets in a box of 10 X 10s