MOZART

MOZART blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues.

MOZART is well absorbed and undergoes substantial first-pass metabolism; the systemic bioavailability is approximately 33%. About 14% of an orally-administered dose is converted to the active metabolite. Mean peak concentrations of MOZART and its active metabolite are reached in 1 hour and in 3-4 hours, respectively. While maximum plasma concentrations and its active metabolite are approximately equal, the AUC of the metabolite is about 4 times as great as that of it.

Hypertension: 50-100 mg once or twice daily Hypertension with LVH: 50 mg once daily Nephropathy in type 2 diabetes: 50-100 mg once daily

Available in 250/500mg tablet. Available as a blister strip of 10 tablets in a box of 10 × 10s.