TOPICLO-BN Cream

Cream contains the dipropionate ester of betamethasone, a glucocorticoid exhibiting the general properties of corticosteroids, and clotrimazole which is an imidazole antifungal agent. Topical corticosteroids are effective in the treatment of a range of dermatoses because of their anti-inflammatory anti-pruritic and vasoconstrictive actions. Clotrimazole is a broad-spectrum antifungal agent with activity against Trichomones, Staphylococci and Bacteroides. Neomycin is an aminoglycoside antibiotic that primarily exerts its effect on bacterial cells by inhibiting polypeptide assembly and synthesis on the ribosome.

Cream intended for treatment of skin conditions and is applied topically. Thus, there are minimal pharmacokinetic aspects related to bioavailability at the site of action. Clotrimazole penetrates the epidermis after topical administration but there is little, if any, systemic absorption. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including vehicle, integrity of skin and use of occlusion. Systemically absorbed topical corticosteroids are bound to plasma proteins metabolised in the liver and excreted by the kidneys. Some corticosteroids and their metabolites are also excreted in the bile. Neomycin is poorly absorbed from the gastrointestinal tract and after topical administration an insufficient amount is absorbed to produce systemic effects. Absorption has been reported to occur from wounds and inflamed skin. After absorption neomycin is rapidly excreted by the kidneys in active form.

Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply a thin layer of the medication to the affected area and gently rub in, usually twice daily (in the morning and evening) or as directed by your doctor. Wash your hands after using unless you are using this medication to treat the hands. Do not wrap, cover, or bandage the area unless directed to do so by your doctor. Wear loose-fitting clothes after applying the medication to the groin area. Do not apply the medication in the eyes, nose, mouth, or inside the vagina. If you do get the medication in those areas, flush with plenty of water. The dosage and length of treatment depends on the type of infection being treated. Ringworm or jock itch is usually treated for 2 weeks, and athlete's foot is usually treated for 4 weeks. Do not use more than 45 grams of the cream or 45 milliliters of the lotion per week unless directed and closely monitored by your doctor. Do not apply more often or use longer than prescribed. This may increase the risk of side effects. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Inform your doctor if your condition worsens or does not improve after 1 week of treatment for jock itch or ringworm or 2 weeks of treatment for athlete's foot.

TOPICLO-BN Cream is available in 10 g of pack filled in laminated tube & packed in carton.