CABTOP

CABTOP inhibits the trans-membrane influx of calcium ions into vascular smooth muscle and cardiac muscle.

Peak plasma concentrations produce between 6 and 12 hours. Bioavailability: between 64 and 90%. Elimination half-life is about 30–50 hours. Steady-state plasma levels of CABTOP reach after 7 to 8 days of consecutive daily dosing.

Coronary Artery Disease The usual initial antihypertensive oral dose is 5 mg once daily, and the maximum dose is 10 mg once daily. Most patients will require 10 mg for adequate effect. Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding to other antihypertensive therapy. Adjust dosage according to blood pressure goals. In general, wait 7 to 14 days between titration steps. Titrate more rapidly, however, if clinically warranted, provided the patient is assessed frequently.

CABTOP 2.5 (Amlodipine 2.5 mg): 10 x 10s CABTOP 5 (Amlodipine 5 mg): 10 x 10s CABTOP 10 (Amlodipine 10 mg): 10 x 10s