• Indication
  • Mode of Action
  • Pharmacokinetics
  • Dosage
  • Packing

PREMAX-PLUS is used for the management of neuropathic pain associated with diabetic peripheral neuropathy or spinal cord injury, and post-herpetic neuralgia. It is also used as adjunctive therapy for adult patients with partial onset seizures and management of fibromyalgia.

Pregabalin binds with the high affinity to the alpha2-delta site (an auxillary subunit of voltage-gated calcium channels) in central nervous system tissues. In-vitro, PREMAX reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function.Vitamin B12 acts on functioning in the production of a material called myelin, which covers and protects nerve fibers

PREMAX is well absorbed after oral administration. PREMAX under fasting condition; Tmax = 1.5 hours; Oral bioavailability = >90% (independent of dose); Time to steady state = 24-48 hour. Volume of distribution= 0.5 L/kg. Vitamin B12 gets bind to intrinsic factor (IF) and form a complex. This IF-B12complex is then absorbed in distal ileum. This absorption is done by a very specific receptor mediated transport system. It is distributed to different cells of the body upon binding to transcobalamin II

1 Capsule orally once daily , or as consulted by your doctor

10 * 10 capsules

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