P-ONE

P-ONE Pyridoxine 10/40/100 mg tab  

Indication

P-ONE is used for preventing and treating low levels of pyridoxine (pyridoxine deficiency) and the “tired blood” (anemia). It is also used for heart disease like high cholesterol, reducing blood levels of homocysteine. Women use pyridoxine for premenstrual syndrome (PMS) and other menstruation problems, "morning sickness" (nausea and vomiting) in early pregnancy, stopping milk flow after childbirth, depression related to pregnancy or using birth control pills, and symptoms of menopause. Pyridoxine is also used for Alzheimer's disease, attention deficit-hyperactivity disorder (ADHD), Down syndrome, autism, diabetes and related nerve pain, sickle cell anemia, migraine headaches, asthma, carpal tunnel syndrome, night leg cramps, muscle cramps, arthritis, allergies, acne and various other skin conditions, and infertility. It is also used for dizziness, motion sickness, preventing the eye disease age-related macular degeneration (AMD), seizures, convulsions due to fever, and movement disorders (tardive dyskinesia, hyperkinesis, chorea), as well as for increasing appetite and helping people remember dreams. Some people use pyridoxine for boosting the immune system, eye infections, bladder infections, and preventing cancer and kidney stones. Pyridoxine is also used to overcome certain harmful side effects related to radiation treatment and treatment with medications such as mitomycin, procarbazine, cycloserine, fluorouracil, hydrazine, isoniazid, penicillamine, and vincristine.

Mode of Action

Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).

Pharmacokinetics

The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum. Protein binding: 22% Hepatic metabolism Half-life: 15-20 days

Dosage and Recommendation

The available dosage of P-ONE are 10/40/100. Pyridoxine Deficiency: 10 to 25 mg/day orally for 3 weeks followed by 2 to 5 mg/day from a multivitamin product. Usual Adult Dose for Anemia Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily. If therapeutic response is not obtained after 1 to 2 months of pyridoxine therapy, a different therapy should be considered. Usual Adult Dose for Nausea/Vomiting Nausea and vomiting of Pregnancy: 25 mg orally every 8 hours.

Packing and Presentation

Each strip contains 10×10s tablets.