PREMAX PLUS

 Pregabalin and Methylcobalamin  75mg/750mcg and 75mg/1500 mcg Capsules

Indication

PREMAX PLUS is prescribed for the treatment of spinal cord injury-related neuropathic pain, fibromyalgia, perioperative pain, migraine, chronic pain and peripheral neuropathy.

Mode of Action

Pregabalin+Methylcobalamin can reduce the release of neurotransmitters and promotes regeneration of neuronal myelin sheath. Pregabalin possess analgesic property and reduce neuropathy-related pain symptoms. Methylcobalamin is a cofactor of methionine synthase for the transfer of methyl groups to generate methionine from homocysteine. Elevated level of homocysteine is a predominant risk factor of CAD. Methionine can be converted into s-adenosylmethionine, which involve in methylation reactions related to reduction of depressive disorders.zfc

Pharmacokinetics

Pregabalin: After oral administration, Pregabalin is rapidly absorbed in GIT. The Cmax can be achieved within one hour after administration. The oral bioavailability is about 90%. The rate of absorption is influenced by food intake. Pregabalin is not bound to plasma proteins. The Vss of Pregabalin is 0.56L/kg. About 98% of the administered Pregabalin is excreted via the urine as unchanged drug. Methylcobalamin: After oral administration, the peak plasma concentration can be achieved after three hours. The vitamin is eliminated in the urine as unchanged drug.

Dosage and Recommendation

Dosage For adults, take one capsule daily or as directed by a physician. Food(before/after) PREMAX PLUS should be taken before food intake.

Packing and Presentation

PREMAX PLUS is available as an Alu-Alu strip of 10 Capsules in a box of 10*10s