ACENIL is used to treat painful rheumatic conditions as osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It eases pain and reduces inflammation.
Mode of Action
ACENIL works by blocking the effect of chemicals called cyclooxygenase (COX) enzymes. These enzymes help to make other chemicals in the body called prostaglandins. Some prostaglandins are produced at the sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation, are eased.
After oral administration of a single 100mg dose, Cmax of 6.8 to 8.9 mg/L were reached in about 1.4 to 2 hours. . The low plasma concentrations and AUC values for the metabolites indicate that ACENIL is principally responsible for the pharmacological activity. Approximately 70% of the drug is eliminated in the urine and 20% in the feces.
Dosage and Recommendation
The usual oral dosage of ACENIL is 100mg twice daily for the treatment of arthritic disorders and moderate to severe pain in adults. ACENIL, like other NSAIDs, should be administered with caution to patients with a history of peptic ulcer or dyspepsia.
Packing and Presentation
Each strip contains 10 tablets.