MOMECOR Nasal Spray

MOMECOR Nasal Spray

Each spray delivers:

Mometasone Furoate IP 50 mcg

 COMPOSITION

Mometasone Furoate                             IP         0.05% w/v

Benzalkonium Chloride Solution            BP        0.02 % v/v

(as preservative)

 DESCRIPTION

A white to off-white colored homogenous re-dispersible suspension.

PHARMACODYNAMIC

Pharmacotherapeutic group: Decongestants and Other Nasal Preparations for Topical Use-Corticosteroids.

ATC code: R01AD09

Mechanism of action

Mometasone furoate is a topical glucocorticosteroid with local anti-inflammatory properties at doses that are not systemically active.

It is likely that much of the mechanism for the anti-allergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of allergic reactions. Mometasone furoate significantly inhibits the release of leukotrienes from leucocytes of allergic patients. In cell culture, mometasone furoate demonstrated high potency in inhibition of synthesis and release of IL-1, IL-5, IL-6 and TNFα; it is also a potent inhibitor of leukotriene production. In addition, it is an extremely potent inhibitor of the production of the Th2 cytokines, IL-4 and IL-5, from human CD4+ T-cells.