LUCAST PLUS

Levocetirizine, the active enantiomer of cetirizine, is an antihistamine; its principal effects are mediated via selective inhibition of H1 receptors. Montelukast blocks the action of leukotriene D4 on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene, and results in less inflammation.

Levocetirizine After oral administration, Levocetirizine is rapidly absorbed in GIT. In adults, peak plasma concentrations are achieved 0.9 hour after administration of the oral tablet. The accumulation ratio following daily oral administration is 1.12 with steady state achieved after 2 days. Food had no effect on the extent of exposure (AUC) of the levocetirizine tablet, but Tmax was delayed by about 1.25 hours and Cmax was decreased by about 36% after administration with a high fat meal; therefore, levocetirizine can be administered with or without food. Levocetirizine is poorly metabolized and mostly excreted via the urine. Half life is 8-9 hrs Montelukast Rapidly absorbed following oral administration (bioavailability is 64%).Montelukast and its metabolites are excreted almost exclusively via the bile. Half life is 2.7-5.5 hours

For adults, take one tablet daily at evening or as directed by a physician. Dosage may be differ according to age of patient.

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