DULOT

DULOT is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine re-uptake. The mechanism of action of DULOT has not been determined, but associated with the potentiation of serotonin and norepinephrine activity in the spinal cord, which increases urethral closure forces and thereby reduces involuntary urine loss.

Orally administered DULOT is well absorbed. Volume of distribution- 1640 L; Protein binding- <90% Metabolites found in plasma include 4-hydroxy duloxetine glucuronide and 5-hydroxy, 6-methoxy duloxetine sulfate. Most (about 70%) of the duloxetine dose appears in the urine as metabolites of duloxetine; about 20% is excreted in the feces. Half-life - 12 hours (range 8-17 hours)

Usual Adult Dose for Depression Initial dose: 20mg orally twice a day Maintenance dose: 60mg per day, given either once a day or as 30mg orally twice a day Maximum dose: 120mg orally per day   Usual Adult Dose for Fibromyalgia Initial dose: 30mg orally once a day for 1 week Maintenance dose: 30 to 60mg orally once a day Usual Adult Dose for Generalized Anxiety Disorder Initial dose: 60mg orally once a day Maintenance dose: 60 to 120mg orally once a day Maximum dose: 120mg orally once a day Usual Adult Dose for Pain Initial dose: 30 to 60 mg orally once a day Maintenance dose: 60mg orally once a day Usual Geriatric Dose for Generalized Anxiety Disorder Initial dose: 30mg orally once a day for 2 weeks, after which an increase to 60mg orally once a day may be considered. Maintenance dose: 30 to 60 mg orally once a day Maximum dose: 120mg orally once a day   Usual Pediatric Dose for Generalized Anxiety Disorder 7 to 17 years Initial dose: 30mg orally once a day for 2 weeks, after which an increase to 60mg orally once a day may be considered Maintenance dose: 30 to 60mg orally once a day Maximum dose: 120 mg orally once a day

Available in 20mg, 30mg and 60mg. Each strip contains 10 tablets