Z-FLO

Z-FLO is a non-subtype specific alpha (1)-adrenergic blocking agent that exhibits selectivity for alpha (1)-adrenergic receptors in the lower urinary tract. Inhibition of these adrenoreceptors leads to the relaxation of smooth muscle in the bladder neck and prostate, resulting in the improvement in urine flow and a reduction in symptoms in benign prostate hyperplasia. Z-FLO also inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Absorption- 50% lower under fasting conditions Bioavailability: 49%, Tmax: 8 hrs Volume of distribution- 3.2 L/kg Protein binding- 82% - 90% Metabolism- Hepatic, only 11% of the administered dose excreted unchanged in the urine. Half-life – 10 hours

For Adults: 10mg once a day

Available in 10mg SR tablet Each strip contains 10 tablets