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ELOPRAM

ELOPRAM tablet

Escitalopram 5/10/20mg

ELOPRAM

  • Indication
  • Mode of Action
  • Pharmacokinetics
  • Dosage
  • Packing

ELOPRAM is indicated for the acute and maintenance treatment of major depressive disorder in adults and in adolescents 12 to 17 years of age. It is also indicated for the acute treatment of Generalized Anxiety Disorder (GAD) in adults, Obsessive-Compulsive Disorder, Insomnia and Vasomotor symptoms associated with Menopause.

ELOPRAM blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1Aautoreceptors, SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.

The absolute bioavailability of escitalopram is about 80% relative to an intravenous dose. Volume of Distribution: 12 L/kg; Protein Binding:  ̴ 56% Metabolism mainly hepatic. ELOPRAM undergoes N-demethylation to S-demethylcitalopram (S-DCT) and S-didemethylcitalopram (S-DDCT). CYP3A4 and CYP2C19 are the enzymes responsible for this N-demethylation reaction. The fraction of drug recovered in the urine as escitalopram and S-demethylcitalopram (S-DCT) is about 8% and 10% respectively. Half-life- 27-32 hours; Oral Clearance= 600 mL/min

Usual Adult Dose for Generalized Anxiety Disorder Initial dose: 10mg orally once a day; increase if necessary after at least 1 week of treatment to 20mg once a day. Maintenance dose: 10 to 20mg orally once a day. Maximum dose: 20mg orally once a day Usual Adult Dose for Depression Initial dose: 10mg orally once a day; increase after at least 1 week of treatment to 20mg once a day. Maintenance dose: 10 to 20mg orally once a day Maximum dose: 20mg orally once a day. Usual Pediatric Dose for Depression 12 to 17 years of age Initial dose: 10mg orally once a day, increase if necessary after at least 3 weeks of treatment to 20mg once a day Maintenance dose: 10 to 20 mg orally once a day Maximum dose: 20mg orally once a day. 18 years or older: Usual adult dose Renal Dose Adjustment Severe renal impairment: Use with caution Liver Dose Adjustment Liver Dysfunction: 10mg orally once a day Dose Adjustment Treatment withdrawal: A gradual dose reduction is recommended instead of abrupt cessation where possible Switching between MAOI and escitalopram therapy: At least 14 days should elapse between ceasing one of these medicines and starting the other.

Available in 5mg and 10mg tablet Each strip contains 10 tablets

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