SONATE

SONATE tablet

Sodium Bicarbonate 300mg

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Indication

SONATE is indicated to treat metabolic acidosis which can occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock, anoxia or severe dehydration, extracorporeal circulation of blood and severe primary lactic acidosis

Mode of Action

SONATE is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration and raises pH, thereby reversing the clinical manifestations of acidosis.

Pharmacokinetics

SONATE raises blood and urinary pH by dissolution to provide bicarbonate ions, which neutralizes the hydrogen ion concentration. It also neutralizes gastric acid via production of carbon dioxide. Rapid onset of action with 8-10 minutes of duration of action

Dosage and Recommendation

Oral Urine Alkalinisation Adult: To prevent development of uric-acid renal calculi in the initial stages of uricosuric therapy for hyperuricaemia in chronic gout: Up to 10 g daily in divided doses, to be taken with a liberal amount of fluid. Elderly: Dosage adjustments may be required. Renal impairment: Dosage adjustments may be required. Hepatic impairment: Dosage adjustments may be required. Oral Chronic Metabolic Acidosis Adult: Doses providing 57 mmol (4.8 g sodium bicarbonate) or more daily as required. Elderly: Dosage adjustments may be required. Renal impairment: Dosage adjustments may be required. Hepatic impairment: Dosage adjustments may be required. Oral Dyspepsia Adult: 1-5 g in water, may be taken as required. Elderly: Dosage adjustments may be required. Renal impairment: Dosage adjustments may be required. Hepatic impairment: Dosage adjustments may be required.

Packing and Presentation

Each bottle contains 100 tablets.